Dragon's Sanctum

Boss	NPCs	Notable Loot	Enemies	Enemy Drops
None	None	Lightning Clutch Ring Flynn's Ring Bloodbite Ring +1 Catarina Helm Sanctum Knight Helm Sanctum Shield Puzzling Stone Sword Sanctum Crossbow Drakeblood Greatsword Drakeblood Set Denial Dragon Stone Eternal Sanctum Key Soul Vessel Bonfire Ascetic 12x Twinkling Titanite	Sanctum Soldier Sanctum Knight Sanctum Priestess Drakeblood Knight Corrosive Egg Insect 4x Crystal Lizard Sanctum Dragon Invader Jester Thomas	Sanctum Mace Sanctum Soldier Gauntlet Sanctum Knight Set Sanctum Crossbow Sanctum Repeating Crossbow Sanctum Priestess Tiara

The Sunken King erected the
Eternal Sanctum to shelter Sinh the Dragon.

The Sanctum appears to be a solemn temple,
but it is filled with devilish creatures that
ensure no trespasser shall cause offense.¹

Hidden Sanctum Chamber
To the left of the bridge above the spiked floor. Activated by hitting a switch on a wall near the narrow, broken staircase. (Video)

Sanctum Interior
Before the two Drakeblood Knights. at the top of a long staircase behind an illusory wall. Above the room with empty chests and the Drakeblood Set.

Dragon's Sanctum Walkthrough Video
Item Guide Part I (from 23min)
Item Guide Part II (up to 17min)
Item Guide Part III

Soul of a Great Hero and 3x Dragon Charm behind the door opened by a switch.
Contents of the chests in the room where you first encounter a Sanctum Knight:
- 50x Destructive Greatarrow
- Catarina Helm
- Soul Vessel
- 5x Old Growth Balm
- Titanite Slab
Bonfire Ascetic in a wooden chest in the Sanctum Soldier ambush corridor.(not working in new patch)
A Human Effigy is in the sand pit with the first Sanctum Priestess.
There is some Repair Powder on the left in the narrow corridor.
Past the staircase with a wall spike trap, there are two wooden chests containing 3x Bleed Stone and 3x Boltstone on the left and on the right, 3x Twinkling Titanite and 3x Petrified Dragon Bones.
On the stairs there is a Soul of a Hero and a Human Effigy.
In the previous room is a fake wall that can be activated with a switch. It's at the end of the long narrow corridor (look up). Behind the wall is a chest containing the Puzzling Stone Sword.
In the room full of Corrosive Egg Insects, pick up 5x Lifegem, 1x Old Growth Balm, 10x Dung Pie and 20x Poison Throwing Knife.
Flynn's Ring can be found above the room full of insects.

On the ground in the spikes, you can pick up 3x Torch, 3x Twinkling Titanite, 5x Holy Water Urn and 1x Human Effigy.
Dragon Stone is found in a metal chest. The door to the chest is opened by hitting a switch.
In the room with three Sanctum Knights and the bodies of many others awaits a Sanctum Knight Helm and the Eternal Sanctum Key.
5x Lloyd's Talisman inside a trapped chest.
Bloodbite Ring +1 is in a chest.
The Denial miracle is behind the circular contraption. Use projectiles to activate the switch behind it.
There is a Sanctum Crossbow on a corpse just past the Hidden Sanctum Chamber bonfire.
Before Jester Thomas, 1x Old Growth Balm.

In the water you can find 3x Petrified Dragon Bone, 3x Human Effigy, Soul of a Great Hero and 2x Dried Root.
Head to the cliff with the Dragon Stone contraption, then go to the elevator room. Found on a corpse to the left of the elevator room is the Drakeblood Greatsword.

One Human Effigy is before the bridge leading to the Sanctum.
10x Hexing Urn near the second Drakeblood Knight.
On a corpse in the room below the Sanctum Interior bonfire is the Drakeblood Set. This room is filled with 5 empty metal chests.
6x Twinkling Titanite, 3x Vine Balm, Large Soul of a Brave Warrior and 5x Small Smooth & Silky Stone near the last set of Drakeblood Knights.

10x Dried Root and Lightning Clutch Ring inside chests behind the Eternal Sanctum Key door.
Continue up the ladders. Sanctum Shield is inside a chest on the top floor.

Great place to farm Twinkling Titanite and Petrified Dragon Bone as there is a free Bonfire Ascetic on the level. Use Ascetics at the Tower of Prayer bonfire in Shulva, Sanctum City to respawn the items.(not working in new patch)

Footnotes 1. Eternal Sanctum Key description.